The Anti-Inflammatory Potential of Selective Cholinergic Agonists
نویسندگان
چکیده
منابع مشابه
Cholinergic Anti-Inflammatory Pathway Dysfunction of the Cholinergic Anti-Inflammatory Pathway Mediates Organ Damage in Hypertension
Inflammatory responses are associated with the genesis and progression of end-organ damage (EOD) in hypertension. A role for the 7 nicotinic acetylcholine receptor ( 7nAChR) in inflammation has recently been identified. We tested the hypothesis that 7nAChR dysfunction contributes to hypertensive EOD. In both spontaneously hypertensive rats (SHRs) and rats with abdominal aorta coarctation–induce...
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The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases from vagus nerve terminals leads to inhibition of inflammatory cytokines through α7 nicotinic acetylcholine receptors (α7nAChRs) which located on ...
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OBJECTIVES Basal forebrain cholinergic neurons are proposed as a major neuromodulatory system in inflammatory modulation. However, the function of basal forebrain cholinergic neurons in sepsis is unknown, and the neural pathways underlying cholinergic anti-inflammation remain unexplored. DESIGN Animal research. SETTING University research laboratory. SUBJECTS Male wild-type C57BL/6 mice a...
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ژورنال
عنوان ژورنال: Shock
سال: 2011
ISSN: 1073-2322
DOI: 10.1097/shk.0b013e31821820d2